ROC analysis

Sample sizes:

22q CR NC SZ
168 19 97 41

Area Under the Curve (AUC): 0.88

PCA

22q group

Scree

Loadings

PC1

PC2

PC3

PC4

Whole sample

Scree

Factor scores

Loadings

PC1

ROC Analysis

Area Under the Curve (AUC): 0.9

PC2

ROC Analysis

Area Under the Curve (AUC): 0.68

PC2: Normal Controls vs Schizophrenia
## 
##  Welch Two Sample t-test
## 
## data:  NC_score and SZ_score
## t = 3.7495, df = 83.679, p-value = 0.0003253
## alternative hypothesis: true difference in means is not equal to 0
## 95 percent confidence interval:
##  0.07023095 0.22887998
## sample estimates:
##   mean of x   mean of y 
##  0.13597450 -0.01358097
## Cohen's d |       95% CI
## ------------------------
## 0.67      | [0.29, 1.04]
## 
## - Estimated using pooled SD.
PC2: Normal Controls vs Clinical Risk
## 
##  Welch Two Sample t-test
## 
## data:  NC_score and CR_score
## t = 3.8668, df = 33.034, p-value = 0.0004897
## alternative hypothesis: true difference in means is not equal to 0
## 95 percent confidence interval:
##  0.08249714 0.26569048
## sample estimates:
##   mean of x   mean of y 
##  0.13597450 -0.03811931
## Cohen's d |       95% CI
## ------------------------
## 0.78      | [0.28, 1.28]
## 
## - Estimated using pooled SD.
PC2: Schizophrenia vs Clinical Risk
## 
##  Welch Two Sample t-test
## 
## data:  SZ_score and CR_score
## t = 0.48897, df = 42.756, p-value = 0.6274
## alternative hypothesis: true difference in means is not equal to 0
## 95 percent confidence interval:
##  -0.07668375  0.12576044
## sample estimates:
##   mean of x   mean of y 
## -0.01358097 -0.03811931
## Cohen's d |        95% CI
## -------------------------
## 0.13      | [-0.42, 0.67]
## 
## - Estimated using pooled SD.
PC3

PC4